Research Articles
Linkage Disequilibrium Association Studies: A Comprehensive Guide for Genetic Researchers and Drug Developers
This article provides a comprehensive framework for understanding and applying linkage disequilibrium (LD) in genetic association studies, tailored for researchers, scientists, and drug development professionals.
Taming the Confounder: A Modern Guide to Handling Population Stratification in Rare Variant Studies
Population stratification presents a distinct and formidable challenge in rare variant association studies, requiring specialized methods beyond those used for common variants.
Network Co-option vs. De Novo Evolution: Mechanisms, Methodologies, and Biomedical Implications
This article provides a comprehensive analysis of two fundamental mechanisms for evolutionary innovation: gene network co-option and de novo gene evolution.
Power Analysis for Rare Variant Association Studies: A Comprehensive Guide for Genetic Researchers
This article provides a comprehensive guide to power analysis in rare variant association studies (RVAS), a critical methodology for uncovering the genetic architecture of complex traits and diseases.
Advanced Grouping Strategies for Rare Variant Analysis: From Statistical Foundations to Clinical Applications
This article provides a comprehensive guide to rare variant grouping strategies, addressing the critical challenge of analyzing genetic variants with low frequency but potentially high impact on disease.
Population Genomic Approaches to Local Adaptation: From Foundational Concepts to Clinical Applications
This article provides a comprehensive overview of population genomic methodologies for identifying local adaptation, a process critical for understanding how species evolve to environmental heterogeneity.
Reconstructing Gene Networks from QTL Data: Methods, Applications, and Best Practices
This article provides a comprehensive overview of modern computational strategies for reconstructing gene regulatory networks (GRNs) from Quantitative Trait Loci (QTL) data.
Gene-Based Burden Tests for Rare Variants: From Foundational Principles to Clinical Applications in Drug Development
This article provides a comprehensive overview of gene-based burden testing, a cornerstone method for identifying associations between rare genetic variants and complex traits.
From Genes to Causality: Leveraging Genotypic Data for Causal Inference in Biomedical Research and Drug Development
This article provides a comprehensive guide for researchers and drug development professionals on establishing causal relationships from observational data using genetic tools.
Integrative Genomics Strategies for Gene Discovery: From Data to Therapies
Integrative genomics represents a paradigm shift in biomedical research, moving beyond single-modality analyses to combine genomic, transcriptomic, and other molecular data for comprehensive gene discovery.